First, as the water freezes and expands, it can create micro-fractures in the glass vial or compromise the seal of the rubber stopper, potentially allowing contaminants in upon thawing
Many communities have pharmaceutical take-back programs or events where medications can be safely disposed of, and some pharmacies offer disposal services for medications they have dispensed
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Above 500mcg/mL, draw volumes drop below 10 units for most research protocols, where insulin syringe graduation marks become unreliable