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Basing on the secondary injury mechanism, a proportion of severe TBI survivors have long-term physical and cognitive disorder, but after high quality care in the emergency or ICU, the consequence may be attenuated

The severity of injuries was assessed immediately after euthanasia

This process prevents cascade oxidative damage to proteins, lipids, and DNAthe building blocks of healthy cells

Cardiac aging in mice is characterized by a decline in diastolic function 29 , which we confirmed by a reduction in the E/A ratio with age in both sexes (Fig