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Neurones of this nucleus are particularly vulnerable to ageing and neurodegeneration and locus coeruleus is arguably the first location being affected in AD

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doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date

The combination of AZD6234 with other incretin-based agents, such as the GLP-1/glucagon dual agonist AZD9550, is also being investigated in a phase 1 trial, with the planning for a phase 2 trial underway

doi:10.15586/codonpublications.parkinsonsdisease.2018.ch1 Parkinsons Disease