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However, it is noted that the clinical outcome of ACI is still variable (Andriolo et al., 2017), and the reasons have not been Frontiers in Bioengineering and Biotechnology | www.frontiersin.org 1April 2021 | Volume 9 | Article 677576 fbioe-09-677576 April 24, 2021 Time: 18:16 # 2 Huang et al

In addition, studies have reported increased expression of growth hormone receptors in tendon-derived fibroblasts following peptide exposure, a response that may amplify regenerative signaling during joint recovery processes (20)

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Methionine is a necessary cofactor in the production of several neurotransmitters