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Aborted LR3 clinical studies in oncology (late 1990s) highlighted the complexity of IGF-1R targeting: mitogenic potential on mammary and prostate tumor lines, requiring abandonment of development in favor of IGF-1R antagonists (monoclonal antibodies such as figitumumab, ganitumab, dalotuzumab) which also encountered phase III failures but enriched understanding of the IGF axis role in carcinogenesis

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