This process leads to the activation of macrophages, the secretion of inflammatory factors, and ultimately, inflammation in cells such as Kupffer cells, as well as hepatocytes, which produce significant amounts of cytokine, particularly TNF- and IL-6 (Allam et al
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Additionally, bidirectional communication between neurons and SCs occurs via paracrine signaling, extracellular vesicles, and direct molecular exchange
doi: 10.1016/j.neurobiolaging.2021.07.014
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