Although degradation-synthesis coupling would be consistent with Figures 3A,B, it is also unexplained why metabolism of GABA should be so important for glutamate production, since GABA in adult animals contributes so relatively little to the return flux toward astrocytes ( V cyc )
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7k, l, in combination with the protein translation inhibitor cycloheximide (CHX), the half-life of GPX4 in ACE-treated cells was faster than that in untreated cells, suggesting that ACE degraded GPX4 mainly at the protein level
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