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In March 2011, the FDA placed the trial on clinical hold due to GMP compliance issues at the contract manufacturer not safety concerns with RGN-352 itself

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Exons 5 and 6 are alternatively spliced and code for three different C-terminal E-peptides: Ea (from exon 6), Eb (from exon 5), and Ec (from a combination of fragments of exons 5 and 6)

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