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Description

105 A combination of melatonin and sulodexide has been tested as a therapy for tinnitus

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This occurs through decreased mRNA expression of cartilage matrix synthesis genes ( Col2a1 and Acan ) and suppression of extracellular matrix signaling pathways, particularly transforming growth factor beta (Tgf)

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Notably, this approach avoids the risks associated with immunosuppression, such as increased infection rates or tumor formation, as confirmed by long-term follow-up studies conducted up to four years post-treatment

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