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Addressing the key scientific questions discussed in this review will improve our understanding of the precise role of ferroptosis in various retinal diseases, thereby providing a new scientific basis for the prevention and treatment of retinal diseases with ferroptosis-targeted drugs

Key Properties: Stable in aqueous solutions Widely available in generic formulations Cost-effective Hydroxocobalamin: Extended Duration Benefits Hydroxocobalamin is another Vitamin B12

Furthermore, intracellular Fe 2+ is pumped into the extracellular space through membrane ferritin 1 (SLC40A1/FPN1) to strictly maintain cellular iron homeostasis ( Many studies have demonstrated that iron metabolism-related proteins could be used as targets to regulate ferroptosis

One promising direction is to repurpose metabolic cues as both assembly triggers and cellular pathway regulators, enabling bidirectional communication between supramolecular nanomaterials and cellular responses

Ethics statement The animal study was approved by Shanghai Ocean University Animal Ethics Committee