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Reports of stability in gastric juice are not the same as systemic bioavailability, and routes of administration in published rodent work include intraperitoneal, oral (drinking water), and topical comparisons across routes are not always controlled in primary studies (Cerovecki et al., 2010)

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Without a priori knowledge of what insults were applied, and in which order, simply observing the final histological lesion renders it impossible to infer the underlying sequence of events nor the initial trigger