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Note: As of January 2023, Modifier JZ was introduced to attest that there was zero drug wastage, and at least one of these modifiers (JW or JZ) is now required on all applicable Medicare drug claims

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Parkinson's disease is characterized by a reduction in dopamine levels due to the loss of dopaminergic neurons in the substantia nigra, resulting in an imbalance between the direct and indirect pathways in the striatum

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