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It acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in multiple tissues including adipose tissue and the liver that plays a role in cellular energy metabolism and fat storage

This is because B12 plays a large role in nerve function and cognition

Young adults may also experience absorption challenges due to MTHFR genetic mutations, food intolerances, digestive disorders, antacid use, excessive alcohol consumption, and smoking

The study authors reinforced the idea that NNMT inhibition could potentially treat obesity and related metabolic comorbidities [6]

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