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We optimize disulfide linker stability by modulating the electronic effects and spatial structure around the sulfur atoms, including introducing steric hindrance groups, designing cyclic disulfide linker ring structures, and applying hydrophilic or hydrophobic modifications at both linker ends

doi:10.1371/journal.pone.0093315 Yang Y, Jin X, Jiang C (2014) S-glutathionylation of ion channels: insights into the regulation of channel functions, thiol modification crosstalk, and mechanosensing

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