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Internal memos from 2021 show that those same toxicologists were barred from seeing data collected from product safety tests, making it impossible for them to monitor what was circulating in the legal market

12,13 In animal models, nicotine leads to endothelial NO synthase (eNOS) uncoupling, increases ROS, and promotes mitochondrial dysfunction

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The change to filter tip products did not prevent a progressive increase in lung cancer risk among male smokers who began smoking during and after the second world war compared to the first world war era smokers No studies have adequately assessed whether health claims used to market reduced yield cigarettes delay cessation among smokers who might otherwise quit, or increase initiation among non-smokers