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All these points may be supported by its special interaction with various molecular pathways [8,11,75,115,116,117,118,119,120,121,122,123], especially with the nitric oxide (NO)-system [121,122,123,124,125,126,127,128,129,130] as a whole

The intricate interplay between glutamine metabolism and PD-L1 expression in the tumor microenvironment has unveiled novel pathways for therapeutic intervention