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The FDA has classified BPC-157 in Category 2 for bulk drug substances, citing possible safety issues in compounding, such as immunogenicity, impurities, and insufficient safety evidence for suggested administration routes

7, July 2004, pp

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Interestingly, among several natural products, cyanidin-3- O -glucoside and catechins were studied and reported as mh-Tyr inhibitors using spectroscopic methods, recently reviewed elsewhere 35