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J., Mourad, J
Cross sectional studies done to assess the association between body composition and stimulated GH release in healthy subjects show that, adult people (mean age 50 yr) have a lower peak GH response to secretagogues (clonidine and arginine), and females had a higher response to arginine when compared to males
The mechanism: GHRH receptor activation primes somatotroph cells to release larger GH stores, while simultaneous ghrelin receptor activation triggers the release signal
We do this to reduce the possibility of peptide tolerance while providing a buffer against potential risks from chronic exposure
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