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The Bioavailability Challenge This is where the conversation about dosage usually misses the mark

Studies have documented analgesic effects comparable to moderate doses of conventional pain medications in animal models, with prolonged duration of action extending beyond the peptide's short plasma half-life suggesting central nervous system mechanisms of action

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Daver NG, Garcia-Manero G, Konopleva MY, Alfayez M, Pemmaraju N, Kadia TM, DiNardo CD, Cortes JE, Ravandi F, Abbas H, Basu S, Jabbour E, Pierce SA, Estrov ZE, Takahashi K, Ning J, Kornblau SM , Sasaki K, Masarova L, Flores W, Allison JP, Sharma P, Kantarjian HM