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Non-steroidal anti-inflammatory drugs and apoptosis in the gastrointestinal tract: potential role of the pentose phosphate pathways

Moreover, quercetin suppressed hydrogen peroxide generation (originating from mitochondria) along with the elevation of mitochondrial peroxisome proliferator-activated receptor- coactivator 1 (PGC-1) mRNA expression (master regulator of mitochondrial biogenesis in the skeletal muscles) and NADH dehydrogenase-4 expression in the e gastrocnemius muscle in mice with SNX surgery

Notably, this mitochondrial compromise further escalates ROS production, creating a positive feedback loop that intensifies cellular damage

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