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Physiological thinning of the teat canal keratin layer before parturition and transient dilation of the teat sphincter after milking are considered key windows for pathogen invasion 186

Lu, R., Kiernan, M

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In addition, rutin upregulates the expression of tight junction (TJ) proteins, reduces endotoxemia, inhibits hepatic and adipose TLR/NF-B signaling, and maintains intestinal barrier stability, thus improving the systemic inflammatory response to effectively inhibit weight gain, adiposity, metabolic disorders and chronic inflammation [126, 127]