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The N-acetyl and amide modifications in NA Epitalon protect against exopeptidase cleavage, potentially increasing the fraction of intact peptide that reaches target cells compared to unmodified Epitalon

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Acknowledgments We thank Richard Miles for his helpful comments

Radionuclide-linked nanotherapeutics connect imaging, dosimetry and localized radiation delivery, with translational issues related to radiolabel stability, normal-tissue dose, long-term retention and sequencing with systemic therapies [72, 74, 85, 89]

Genetic variations in enzymes involved in one carbon metabolism, such as the MTHFR gene, can also reduce methylation efficiency