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AARS1 lactylates Yes-associated-protein (YAP) at K90 and TEA-domain-transcription-factor-1 (TEAD1) at K108, forming a positive feedback loop that strengthens Hippo pathway output in gastric cancer [44], whereas AARS2 modifies cyclic-GMP-AMP synthase (cGAS), pyruvate-dehydrogenase-E1-alpha (PDHA1) and carnitine-palmitoyltransferase-2 (CPT2), dampening DNA sensing and oxidative metabolism when mitochondrial lactate accumulates [45]

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It was like a dialled-down Islay mixing it up with a Jamaican pot-still bruiser (with a Versailles acting as referee), and was, in my estimation, something of an original to sample, blending both the traditional rummy flavours with something new

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