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The ileocecal valve or ICV is a one-way door between the small and large intestine that prevents bacteria and archaea from moving backward

Therefore the overall impact on fertility that ROS has is not a matter of if it is there or not (as mentioned earlier, some oxidative stress is required for various reproductive physiological functions), but when levels of ROS are too high (or antioxidant levels are too low) it becomes pathological to sperm and the ability to get pregnant

PMID: 36257906 Invest Ophthalmol Vis Sci Regulatory Effects of the Wnt7b/-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia

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2024 Oct;72(10):32613264