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10.1016/j.jad.2020.05.026 5 ChenY.LiS.ZhaoJ.CaoX.WangF

Additional research is exploring its role in angiogenic signaling, cellular turnover, and oxidative stress response pathways

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

By month3-6, increased libido, lean muscle mass, additional 5-10% weight loss when added to other injectable weight loss medication, more belly fat reduction, etc

10.1006/excr.1998.4287