The small second-order rate constant for the simulated reaction between GSH and the complex of reduced PfGrx C88S and roGFP2 WT (S 2 ) might reflect a poor accessibility of the 1st glutathione interaction site in this complex (Fig
We would like to acknowledge the technical contributions of the Zurich Integrative Rodent Physiology (ZIRP) and the Functional Genomics Center Zurich (FGCZ) of University of Zurich and ETH Zurich for the support on Genomics analyses
The catalytic subunit of glutamate cysteine ligase (encoded by the gene Gclc ) catalyzes a rate-limiting step in glutathione synthesis from the substrates glutamate and cysteine [216]
in contrast, reperfusion after hypovolemic shock is dominated by hypoxia-driven pathways with a less pronounced cytokine storm, while surgical reperfusion (e.g., during liver transplantation) is typically controlled, whereas heat stroke-related reperfusion occurs abruptly during cooling, exacerbating mitochondrial dysfunction
The two routes and compartments do not overlap, so co-ingestion timing is irrelevant from an absorption standpoint
