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Early indicators may begin to appear within days to weeks and often include improved energy levels, reduced fatigue, and better concentration

Proposed mechanisms include fibroblast migration and proliferation, modulation of growth-factor signalingincluding EGF and VEGFand changes in reticulin and collagen-fiber formation at injury sites

However, data from the CDC in 2025 indicates a shift, with the prevalence now estimated at 1 in 31 children in the U.S., reflecting a slight decrease in the rate of diagnosis (Shaw et al

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