Food especially protein may increase peptidase activity in the gut and reduce what gets absorbed
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Medical News Today
Certain medications deplete folate levels
PubMed Seiwerth, S., Rucman, R., Turkovic, B., Sever, M., Klicek, R., Radic, B., Drmic, D., Stupnisek, M., Misic, M., Vuletic, L.B., & Sikiric, P