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Overall, the available data support a cautious model in which mitochondria in the apical domain of PACs function as local ATP suppliers and Ca 2+ buffers that help maintain the secretory apparatus under physiological conditions, whereas mitochondrial failure in AP may indirectly destabilize the granule-rich apical region and facilitate pathological zymogen activation

But not all glutathione supplements are the same

GSH, a potent reducing agent, donates electrons to disulfide bonds in the nanogels, initiating a thiol-disulfide exchange reaction

Our approach enabled us to test four different hypotheses (Table 1) regarding the impact of preparation conditions on plasma GSH measures