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1.2.5 Complications and their risk Severe cases of high altitude illness can lead to potentially fatal complications: High Altitude Pulmonary Edema (HAPE): HAPE is non cardiogenic pulmonary edema caused by acute severe hypoxia, which leads to pulmonary vein vasoconstriction, causing a sharp increase in pulmonary arterial pressure, local hyperperfusion, increased pulmonary blood flow, and imbalanced ventilation blood flow ratio