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While the significance of this finding remains to be determined, it is probably worth mentioning that a decrease in the number of large myelinated axons in rat caudal nerves was observed in all animals until day 30, with a markedly greater number in controls and fewer in injured rats that received BPC 157 treatment

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These include (1) tetrahydrobiopterin (BH 4 ), synthesized by the GTP cyclohydrolase 1 (GCH1)6-pyruvoyl-tetrahydropterin synthase (PTS)sepiapterin reductase (SPR) metabolic pathway and regenerated by dihydrofolate reductase (DHFR) 11