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In bone healing models (segmental defect models in rat femur), BPC-157 administration accelerated callus formation and mineralization, effects consistent with enhanced vascularization of the healing zone since bone formation is tightly coupled to angiogenesis through VEGF-driven osteoblast recruitment

Techniques such as enzyme assays and mass spectrometry are used to measure NADPH concentrations and assess how shifts in NADPH production impact cellular functions