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For prohibition, a substance or method must meet at least two of the following criteria based on a decision made by the WADA List Committee: This framework enables WADA to address both established performance-enhancing agents and new substances that present health or integrity risks to sport

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Wang J, Gao Y, Xiao L, Lin Y, Huang L, Chen J, et al

The volume of distribution and the half-life need not be known in order to determine the average plasma concentration expected from a given dosing rate or to predict the dosing rate for a desired target concentration