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The tissue and cell disruption during processing (e.g., mixing, cutting, crushing, freezing/thawing, and high pressure treatment) makes native polyglutamyl folates accessible for endogenous conjugases (-glutamyl hydrolases) and results in the hydrolysis to monoglutamyl folates in vegetables (e.g., leeks, cauliflower, broccoli, spinach, soybeans, green beans, cowpea leaves, turnip, and carrot) and fruits (e.g., orange, papaya, sweet cherry, strawberry, and blackberry)

Then, these effects were confronted with administration of anticoagulants without or with amputation

However, cross-resistance to -lactam antibiotics and -lactamase inhibitors has been documented 91,92 , which makes such combination therapy ineffective 93,94

A hypothesis incorporating the gut microbiome, gender predilection, and differential methylation is presented