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Compared to the UBE2m RK, the re-introduction of UBE2m WT promoted NEDD4 neddylation in UBE2mKO HK-2 cells, while NEDD4 neddylation could not be induced by the vector alone (Fig
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Chronic Impacts of Pediatric Obesity Despite extensive studies of comorbidities in childhood obesity, only few, robust, longitudinal investigations have explored the metabolic and molecular underpinnings in adulthood, possibly due to the lengthy follow-up and extensive resources required [226,227,228,229] Relative risks ranging from 1.7 to 5.4 for type 2 diabetes, hypertension, dyslipidemia and cardiovascular diseases, and a 16.6% increased risk of multi-morbidities have been reported in adults with persistent obesity from childhood [230,231,232]
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