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While GLP-1 analogs for treatment of type 2 diabetes cause mild-to-moderate nausea and vomiting in a significant proportion of patients, their benefits in terms of weight loss and improved glycemic control have allowed the class to overcome these tolerability concerns and become one of the most-prescribed classes of type 2 diabetes medications in the US and Europe (326)

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A more successful general strategy has been to utilize DNA binding proteins that block the terminal ends of the LET, 204206 which in one case resulted in LET-based expression on par with that of plasmid-based expression

Measurement: 1.0 mg equals 3 units, 1.5 mg equals 4.5 units, and 2.0 mg equals 6 units

Specifically, it produces no IGF-1 elevation (avoiding proliferative concerns), no negative impact on glucose metabolism (avoiding diabetes risk), no fluid retention or edema, and no concerning patterns of joint pain that can occur with growth hormone