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In summary, while there is a significant number of contender approaches for clinical trials, we should privilege those with a higher chance of not only being efficient, but also having a realistic potential of being established as a treatment for SCA3

The mitogen-activated protein kinases (MAPKs) family, including extracellular signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, and c-Jun NH2-terminal kinase (JNK1/2), has been shown to play a significant role in the mediation of signals triggered by cytokines, growth factors, and environmental stress and is involved in various cellular functions [9, 10]

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