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In human studies, it was described as 'incredibly safe' with no lethal dose ever identified in animal studies

In adipose tissue, we observed that CI respiration was rhythmic across gWAT and iWAT, and was reduced by Bmal1 loss, whereas respiration through CIICIV was not affected by loss of the clock

Furthermore, a recent meta-analysis documented alterations in superior frontal, lingual gyrus, hippocampus, insula, putamen, superior temporal, inferior temporal gyrus, and anterior cerebellum in the brains of patients with major depression who had a history of ACE [69]

Originally identified in human plasma, GHK-Cu is composed of the amino acid sequence glycyl-L-histidyl-L-lysine bound to copper ions

Immunity 54 , 14631477 (2021)