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New England Journal of Medicine , 251 (5), 161168

Serum N(1)-methylnicotinamide is associated with obesity and diabetes in Chinese (in Eng)

In this case, the body cannot absorb B12 from food because it lacks a necessary protein

Excess methionine could lead to irritability or a powerful sulfur odor

This forms a complete regulatory cascade:NNMT inhibition NAD+ elevation metabolic optimization This unique mechanism makes 5-amino-1-methylquinolinium injection a critical tool linking NNMT activity, nicotinamide metabolism, and systemic metabolic homeostasis, providing direct experimental support for exploring NNMT's role in energy metabolism