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Phase 3 trials are currently ongoing and will provide data on longer treatment durations, maintenance protocols, and discontinuation outcomes specific to retatrutide

This is one of the key drivers of mitochondrial failure, accumulation of irreparable DNA damage and cellular aging across tissues

Under oxidative stress, GSH is oxidized to glutathione disulfide (GSSG), and redox reactions are catalyzed by glutathione peroxidase (GPx) and GSSG reductase 38

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Therefore, intracellular GSH depletion or GPX4 inactivation induced by various factors will decrease the clearance rate of toxic lipid peroxides and result in ferroptosis