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J Exp Clin Cancer Res , 2015, 34: 111 Wang J, Sun Z, Wang S, Zhao C, Xu J, Gao S, Yang M, Sheng F, Gao S, Hou Y

The antioxidant action of DTPA is derived from its ability to chelate Fe 3+ and thus prevent its reaction with superoxide and hydrogen peroxide, leading to formation of hydroxyl radicals (i.e., preventing HaberWeiss and Fentons reactions) ( 3+ DTPA is slowly reduced by superoxide, which results in the production of fewer hydroxyl radicals (Rahhal and Richter, 1988)

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(2015) 6-month trial at doses up to 1,000 mg/day reported no significant adverse events [12]