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In T2D patients, insulin-mediated inhibition of lipolysis is thought to be impaired, thereby increasing plasma FA levels and ectopic accumulation of TAGs in key insulin sensitive tissues leading to insulin resistance (186)

Sensitivities can be debilitating, affecting various tissues such as the gut, brain, joints, and thyroid, often leading to symptoms like inflammation, brain fog, headaches, and fatigue

286 Besides, -catenin responsive transcription (CRT) is another crucial therapeutic target in combating various cancers and CRT-inhibitory drugs (iCRT3, iCRT5, iCRT14) are specifically cytotoxic to human colon cancer cells and enhance the infiltration of T and NK cells in syngeneic mouse models of CRC by blocking -catenin/TCF interaction