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10.1016/j.taap.2013.03.019 Toxicol

Identifying which neurons govern resilience mechanisms in AD may offer important insight towards targeted future therapies

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Some JAK inhibitors are effective against one isoform, like decernotinib (under phase III) inhibits only JAK3, AC-410 (under phase I) inhibits only JAK2, and filgotinib (under phase III) [80], and INCB-047986 (under Phase I) inhibits only JAK1, are under clinical investigations