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Insulin primarily enters the brain via selective, saturable transport across the blood-brain barrier (BBB) 373,374,375 Peripherally produced insulin can also be actively transported into the brain via an endocytic-exocytic mechanism

From focal aware seizures to the more serious tonic-clonic type, these can lead to permanent brain damage

There are exceptions

A large systematic review did not find a significant reduction in implantation rates (RR = 0.83, 95% CI: 0.681.01, P = 0.07), clinical pregnancy rates (RR = 0.94, 95% CI: 0.831.07, P = 0.35) or livebirth rates (RR = 0.92, 95% CI: 0.831.02, P = 0.10) in mild/moderate endometriosis, although fertilization rates were significantly lower (RR 0.93