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The two agents work on different receptor systems amylin receptors and GLP-1 receptors respectively producing additive weight loss that exceeds what either drug achieves alone

ES NDs effectively reduce the abnormal accumulation of Fe 2+ , GPX4 inactivation, and lipid peroxidation in chondrocytes, thereby improving the metabolic disorders of chondrocytes caused by ferroptosis, and show significant therapeutic effects in alleviating OA

Critical Quality Attributes (CQAs): The target particle size for optimal absorption must stay between 80nm and 200nm to ensure the vesicles move through the gut wall effectively