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In contrast, cleavable linkers (including pH-sensitive hydrazone bonds, reduction-sensitive disulfide bonds, and enzyme-sensitive peptides) achieve controlled release by responding to specific biochemical triggers within the tumor microenvironment or cytoplasm

Tendons are composed of dense, fibrous connective tissue that receives very little vascularization compared to muscle

doi: 10.1097/HEP.0000000000000004 2

Side effects of methotrexate therapy for rheumatoid arthritis: a systematic review

Mucosal Immunol 10:15531568 Matarrese P, Straface E, Pietraforte D et al (2005) Peroxynitrite induces senescence and apoptosis of red blood cells through the activation of aspartyl and cysteinyl proteases