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RCTs show that VE supplementation fails to significantly improve prognosis, functional markers, or quality of life in advanced HF patients (Keith et al., 2001)

Would restoring mitochondrial functioning improve conditions associated with mitochondrial dysfunction? Restoring glutathione Restoring glutathione in cells was not straightforward because glutathione cannot work if taken orally for the same reasons that diabetic patients cannot eat insulin

Mechanistically, glutamine limitation decreases GSH levels and sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA) glutathionylation, resulting in reduced SERCA activity 58

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Rippa, S., Zhao, Y., Merlier, F., Charrier, A