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In the phase 2 trial, 41% to 63% of participants receiving cagrilintide (0.3 to 4.5 mg) experienced gastrointestinal adverse events, compared to 32% with placebo

Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]

In those malignant MCA infarctions, edema generally peaks between 48 and 96 h after the onset, with a fatal outcome in 80% of patients in the first week (76, 82)

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Side Effects & Safety Current knowledge of Dihexa's safety profile is primarily based on animal studies, with no formal human safety data available