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Western blot analysis of thoracic aorta proteins showed that the classic aging markers P21 and P16 were significantly downregulated following FOXO4-DRI treatment, whereas the expression levels of the cell proliferation marker Ki-67 and Lamin B, a key protein involved in nuclear structural stability, were markedly upregulated (Figure 1A)

However, there are specific circumstances when patients should seek medical advice regarding B12 levels and related concerns

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doi: 10.1016/j.cmet.2006.03.005

Although we also included safranal in the search, due to its great antioxidant potential [23], we did not find any clinical studies with this antioxidant in this population