does one cigarette affect your lungs may seem harmless but its effects are far from it. Even a single cigarette releases harmful chemicals that start damaging immediately. Over time, repeated exposure leads to reduced Smoking Effects on Lungs -

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Smoking cigarettes can increase gastric acid production as nicotine, a component released by tobacco smoke, activates receptors in the stomach lining when it reaches the brain

Exposure and metabolic activation biomarkers of carcinogenic tobacco-specific nitrosamines